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This article originally posted 21 July, 2010 and appeared in  Type 2 DiabetesIssue 531CKD and Nephrology

Test Your Knowledge #531: A Caucasian Man with Newly Diagnosed Type 2 Diabetes and Renal Insufficiency, Part Three of Three

Mr. Johnson is a 58-year-old Caucasian who presents for evaluation of his Type 2 diabetes, discovered 6 months ago by a random glucose measurement of 250 mg/dL using his wife's blood glucose meter. Mr. Johnson visited his physician a few days later at his wife's request and had an A1c measurement of 7.5%. 

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Despite his physician's recommendation at that time to go on medication to treat his diabetes, Mr. Johnson insisted he felt fine and wanted to try diet and exercise to see if he could avoid medication. He stated that his wife, who also has Type 2 diabetes, had the knowledge to help him with the changes.

In addition to his diabetes, Mr. Johnson has a 17-year history of hypertension and dyslipidemia, neither of which were well-controlled until 3 years ago

  • Had a cardiac catheterization 3 years ago and was diagnosed with mild diffuse cardiovascular disease, but an intervention was not indicated at that time
  • Has stable angina
  • Was diagnosed with renal insufficiency 2 years ago

During the visit, Mr. Johnson, who works as a construction supervisor, explained that he has had an increase in the amount of stress in his life during the past 6 months and that he has not been very successful at watching his diet. This has been putting a strain on his marriage and he states he now realizes he needs to get control of his diabetes in order to improve both his health and his marriage.

 Case Details
Physical exam / review of systems
Laboratory values

Overweight male in no acute distress

A1c 8.3%
Height 71 inches

Fasting glucose average: 170 mg/dL

Weight 245 lbs

(Self-monitored the week prior to the visit)

BMI 34.2 kg/m2

2-hour postprandial plasma glucose: 270 mg/dL

Blood pressure 136/88 mmHg

(Self-monitored once after dinner)

1+ ankle edema
LDL 92 mg/dL
Foot exam normal
HDL 43 mg/dL

Most recent eye exam 10 months ago; no retinopathy at that time

Triglycerides 160 mg/dL

  
Creatinine 2.0 mg/dL
Current medications
BUN 49 mg/dL
Potassium 4.4 mEq/L

Simvastatin 40 mg daily

Estimated glomerular filtration rate (GFR) 37 mL/min

Ramipril 20 mg daily

Microalbumin 310 µg/mg creatinine

Hydrochlorothiazide 25 mg daily

 
Aspirin 81 mg daily

 

 

Treatment Plan 

The treatment options were discussed with Mr. Johnson and his wife, and it was decided that he would start sitagliptin 50 mg daily. Mr. Johnson stated he preferred to start treatment with a medication that was less likely to cause weight gain and had a low incidence of side effects.  

A prescription was also given for furosemide 40 mg daily to improve his hypertension and 1+ ankle edema. 

After a serious discussion with his physician, Mr. Johnson stated that he now understood how important good glycemic control is to improving his Type 2 diabetes, preventing further decline in his renal function, and decreasing his cardiovascular disease risk. He was told that lifestyle changes could be just as important as medication in improving his health, and he agreed to attend a series of diabetes self-management education (DSME) classes with his wife.

Follow-up 

Three months after his initial visit, Mr. Johnson and his wife returned for a follow-up visit. Mr. Johnson reported he was tolerating the medication well and that he had learned a great deal from the DSME classes taught by a nurse and a dietitian, both of whom were diabetes educators. Although the class format and group support was nice, he found he still had some questions about how much protein and salt he should eat due to his kidney disease and hypertension.  

He reported that even though he learned that sitagliptin is unlikely to cause hypoglycemia, he is now self-monitoring his blood sugars occasionally after meals, and this was helping him adjust his diet and portion sizes. However, he was still having difficulty finding time to exercise, but he was walking with his wife after dinner for 20-30 minutes several days a week.

His wife said she was much happier now that her husband was taking better care of himself and she reported that her A1c had also improved.

Follow-up
 
Laboratory values
 
Follow-up visit
(today)

Previous clinic visit
 (3 months prior)

Weight
240 lbs
245 lbs
Blood pressure
124/76 mmHg
136/84 mmHg
A1c
7.6%
8.3%
Fasting blood glucose
152 mg/dL
170 mg/dL
2-hour average postprandial glucose
185 mg/dL
270 mg/dL
Creatinine
1.9 mg/dL
2.0 mg/dL
LDL
88 mg/dL
 
HDL
46 mg/dL
43 mg/dL
Triglycerides
145 mg/dL
160 mg/dL
Ankle edema
Resolved
1+
 

A. Continue the current medication regimen.
B. Add glipizide ER 5mg daily to improve glycemic control.
C. Increase simvastatin to 80 mg daily to reduce risk of cardiovascular disease.
D. Encourage further lifestyle interventions.
E. Answers B and D.
 

For the correct answer, please click here.

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This article originally posted 21 July, 2010 and appeared in  Type 2 DiabetesIssue 531CKD and Nephrology

Past five issues: Diabetes Clinical Mastery Series Issue 85 | Issue 626 | Special Edition - Getting Patients on Track | Diabetes Clinical Mastery Series Issue 84 | Issue 625 |

 
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