Using an Antiseptic Mouth Rinse May Improve Blood Glucose Control

The randomized, controlled, crossover study conducted at the University of Medicine and Dentistry of New Jersey found that participants using Listerine® Antiseptic as directed experienced a reduction in aerobic and anaerobic bacteria in the blood stream (67.3% and 70.3%, respectively). Anaerobic bacteria are the type most associated with gum disease.

The study involved 22 subjects with a confirmed diagnosis of mild to moderate gingivitis. Blood was drawn from each patient to establish baseline bacteremia levels. Then, subjects took three bites of an apple to induce bacteremia. Blood was drawn again approximately two minutes after the first bite was taken to determine the bacteremia level. Subjects were provided with an assigned mouth rinse (control or Listerine® Antiseptic), as well as a toothbrush, commercial fluoride toothpaste, and a diary to keep a detailed record of their rinsing and brushing. Patients were instructed to rinse with 20 mL of their assigned mouth rinse for 30 seconds, twice daily for two weeks. On Day 15, subjects returned to the clinic and had a new sample taken to determine the level of bacteremia in their blood after treatment. Following a wash-out period, the study protocol was repeated with participants using the alternate mouth rinse.

"The findings from this study serve as compelling evidence to further the theory that plaque and gingivitis germs that migrate from the mouth to the bloodstream may contribute to broader health problems such as diabetes and heart disease," said Daniel H. Fine, DMD, chair of the Department of Oral Biology at the University of Medicine and Dentistry of New Jersey and lead investigator of the study. "While additional research in this area is necessary, this study undoubtedly proves that LISTERINE® Antiseptic kills the germs in your mouth that cause plaque and gingivitis before they have a chance to travel to the bloodstream."

"The study presented at ADA will be the first in a new generation of research evaluating whether a regular oral hygiene regimen with Listerine Mouthwash can have a positive effect on whole body health."

As a way to illustrate recent scientific developments in the connection between oral and systemic health in people with advanced gum disease, the makers of LISTERINE® Antiseptic have developed an educational video, available at http://www.listerine.com/health, for consumers and dental professionals.