Endurance Training Cuts Lipid-Induced Insulin Resistance
Endurance training seems to lessen the effect of lipid-induced insulin resistance, specifically by preventing lipid-induced reduction in nonoxidative glucose disposal (NOGD)....
Advertisement
Esther Phielix, from the Maastricht University Medical Center in the Netherlands, and colleagues examined whether high oxidative capacity, seen in endurance-trained athletes, could attenuate lipid-induced insulin resistance. The study included nine endurance-trained and 10 untrained subjects, Participants underwent a clamp with infusion of glycerol or intralipid.
The researchers found that trained athletes had significantly higher mitochondrial capacity and insulin sensitivity (~32 and ~22 percent, respectively). Insulin-stimulated glucose uptake was reduced by lipid infusion by 63 percent in untrained subjects, and this effect was attenuated in trained subjects (29 percent). Lipid infusion reduced oxidative and NOGD in untrained subjects, while trained subjects were protected from lipid-induced reduction in NOGD.
"Overall, from the current study, we conclude that chronic exercise training attenuates lipid-induced insulin resistance by preventing a reduction in NOGD," the authors write. "In the future, more mechanistic studies are needed to fully understand the mechanism by which endurance training affects lipid-induced NOGD."
DISCLAIMER: The content of this Website is independent of the views of our advertisers and sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.
Copyright @ 1999-2013 Diabetes In Control, Inc.. All rights reserved.
