Gluten Not Linked to Babies' Risk of Diabetes

The findings undercut previous studies, including work from the same scientists, suggesting that babies exposed to gluten as part of their early diet might be more likely to develop type 1 diabetes later in childhood. 

Dorothy Becker, director of the diabetes program at Children's Hospital of Pittsburgh, stated that, "Although the new study included only 150 children, the results are reasonably clear." "It doesn't mean that it if you did a huge study there wouldn't be an effect (of gluten)," said Becker, who was not involved in the study. "But it makes it unlikely." 

Gluten is the protein in wheat and other grains that makes dough elastic and gives bread its chewiness. Roughly 1 percent of people in the United States have a condition called celiac disease, in which immune reactions to gluten damage the intestines. 

Each year about 20 kids per 100,000 under the age of 10 in the U.S. are diagnosed with type 1 diabetes and many of them likely inherited a genetic predisposition to the disease from their parents. Yet genes alone don't fully explain why people develop the condition. Other factors, such as environmental exposures, are thought to be necessary to trigger it. 

In the latest study, the researchers followed 150 babies with at least one parent or sibling who had been diagnosed with type 1 diabetes. Half of the children were exposed to gluten in their diet for the first time at the age of six months. For the rest, exposure to the protein was delayed until after their first birthday. 

The different diets appeared to have no impact on the babies' ability to grow or gain weight. By age 3, three children exposed to gluten early had developed type 1 diabetes, compared to four in the late-exposure group. Signs that the children had developed immune reactions to their own islet cells - a possible precursor to diabetes, especially in those with a genetic predisposition for the disorder - appeared in 11 children given gluten at six months of age, compared to 13 who first ate gluten when they were 12 months old. 

Some research has suggested that delaying exposure to gluten can increase the risk of developing celiac disease. However, the German scientists said they found no evidence for such a link. 

Roughly 30 percent of parents said they did not strictly follow the diet plan. Still, the researchers said, the results of the study show that although delaying the introduction of gluten into a baby's diet causes no harm, it doesn't appear to reduce the risk of diabetes or immune-related early-indicators of insulin problems. 

Research into other potential food triggers for type 1 diabetes is ongoing. Last November, researchers in Finland reported that babies with a genetic predisposition for type 1 diabetes who were fed an infant formula called Nutramigen were about half as likely as those given conventional cows' milk formulas to show signs of islet cell autoimmunity later in childhood. The milk proteins in Nutramigen (sold as Enfamil by Mead Johnson & Co.) are altered in a way that makes them more tolerable to the immune system. The results of that study, which includes nearly 2,200 babies, are expected in 2017.