The retrospective cohort study collected data from the Tennessee Medicaid program and included 28,858 children 6 to 24 years of age, who were recently administered antipsychotic drugs, and 14,429 matched controls. Newly diagnosed diabetes during follow-ups were used to measure the main outcome of the study.
According to the data, risperidone was the most commonly used medication (n=10,718; 37%). The results have shown that children using antipsychotic medication were three times more likely to have type 2 diabetes (HR = 3.03 [95% CI = 1.73-5.32]) within the first year of follow-up. Moreover, the risk also increased with higher accumulative dose. Furthermore, the risk of developing type 2 diabetes remained high up to 1 year after discontinuing use of antipsychotic. When the study was restricted to children 6 to 17 years of age, the risk of type 2 diabetes remained three times higher in children using antipsychotic medications (HR = 3.14 [95% CI = 1.50-6.56]).
Based on the findings, researchers concluded that children and adolescents who are prescribed antipsychotic medications for mental conditions such as mood disorders, attention-deficit/hyperactivity disorder have a higher risk of developing type 2 diabetes.
Bobo W; Cooper W, Stein M,et al. Antipsychotics and the Risk of Type 2 Diabetes Mellitus in Children and Youth. JAMA Psychiatry. 2013