In part 2 of this Exclusive Interview, Alpana Shukla talks with Diabetes in Control Medical Editor Joy Pape about the between the real-world study of food order vs protein preload studies.
Alpana Shukla, MD, MRCP (UK) is Assistant Professor of Research in the Division of Endocrinology, Diabetes & Metabolism at Weill Cornell Medical College in New York.
Transcript of this video segment:
Pape: So, how is this different from giving a protein preload before a meal?
Shukla: So, as you know, Joy, there have been a lot of studies which have looked at giving protein preloads and the most common thing that they’ve used is whey protein. And in a sense the results and the methods looks similar to what our Food Order study shows. But the two key differences as I see it, one of them being that our study is a real world study. This is what people actually eat. It’s a real meal. And also, when you introduce a protein preload you’re changing the calories, you’re changing the macronutrient composition. This is not what people actually eat and it’s a difficult thing to implement in practice. The second important difference between these two interventions is that when you give a protein preload prior to a meal, it stimulates a greater insulin response. The glucose is lower but you stimulate more insulin secretion. However, when you have your protein and vegetables first and have your carbohydrates last, you have a much lower glucose response but you also require less insulin to dispose the same amount of carbohydrate when you eat it last as opposed to eating it first.