Tuesday , November 21 2017

Facts

Brief Interruption of Sedentary Behavior Improves Glucose in Children

Researchers evaluated 28 children aged 7 to 11 years with normal weight to determine whether glucose tolerance could be improved by interrupting sitting with short, moderate-intensity walking bouts. In a random order and on different days, participants underwent one of two conditions: continuous sitting for 3 hours or sitting interrupted …

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Novo Nordisk Gives Up on Victoza in T1D

Lackluster results for liraglutide as adjunct to insulin therapy: Novo Nordisk announced that it will not pursue an expanded indication for liraglutide (Victoza) as an add-on treatment to insulin for type 1 diabetes because of disappointing phase III trial results. The company released top-line results for the ADJUNCT ONE randomized …

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Novo Moving Once-Daily Oral Version of Semaglutide Into Phase 3 Trials

They decided to initiate a phase 3a program with oral semaglutide; a once-daily oral formulation of the long-acting GLP-1 analogue semaglutide. The decision follows the encouraging results of the proof-of-concept phase 2 trial and the subsequent consultations with regulatory authorities. Novo Nordisk intends to initiate a global phase 3a program, …

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Hyperglucagonemia Risk Higher with Liraglutide

Liraglutide induced an enhanced post-challenge insulin and C-peptide response after the 12-week oral glucose tolerance test and throughout the study period, as well as a reduced post-challenge glycemic excursion, but also increased post-challenge glucagonemia among patients with type 2 diabetes, compared with those who received placebo injection. Researchers noted three …

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Study Finds No Bone Health Benefits from Vitamin D Supplements

A University of Wisconsin-Madison study found vitamin D-deficient, postmenopausal women who took high doses of vitamin D increased their calcium absorption by just 1% and saw no gains in spine, hip or total body bone mineral density. Dr. Rita Redberg at the University of California at San Francisco commented that …

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Exercising Early in Life Reduces Diabetes Risk Later

The findings, based on 300 children whose insulin resistance was monitored annually from ages 9 to 16, may indicate that reducing the peak in insulin resistance in adolescence lessens the strain on insulin-producing cells and reduces the risk of diabetes later in life, researchers said. Insulin resistance rises dramatically from …

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The Reason for Higher Health Costs for Diabetes

Any new medications will be over $300 a month, which is one of the main reasons for higher costs for those with diabetes. The other high cost is for inpatient care. A study in Diabetes Care found that patients with diabetes had more than twice the unadjusted mean direct health …

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Older Women Benefit From Increased Aerobic Exercise

Older women who fit more minutes of heart-pumping exercise into their week will lose more body fat, a new study shows. Researchers found that postmenopausal women who got five hours of moderate-to-vigorous aerobic exercise every week — double the normally recommended amount — lost significantly more body fat within a …

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Therapeutic Effects of Metformin in Liver Disease

Researchers at McGill University Health Centre, Montreal, Canada, report that metformin has some biochemical properties effects that would suggest a benefit in treating chronic liver diseases. They searched the PubMed and Ovid MEDLINE databases from 2000 to March 2015, but were unable to find any evidence pointing to an independent …

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