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Adiponectin Level Related to Insulin Sensitivity in Children

Oct 18, 2005

Adiponectin levels correlate with insulin sensitivity in children and adolescents and are lower among African Americans.

Dr. Barbara A. Gower from University of Alabama at Birmingham said that, "We cannot assume that ‘one size fits all’ with respect to disease risk factors. Genetic background, she said, "is an important modifier of the interrelationships among obesity and risk for chronic metabolic disease."

Dr. Gower and colleagues measured adiponectin levels in 67 black and 83 white children and evaluated whether they were related to body fat distribution or insulin sensitivity.

Measures of adiponectin were significantly lower and fasting insulin and acute insulin response to glucose were significantly higher in African Americans than in Caucasians, the authors report.

Adiponectin levels directly correlated with insulin sensitivity and both were inversely associated with all measures of body fat.
In multiple linear regression models, adiponectin related positively to insulin sensitivity. In contrast, body fat distribution did not significantly predict insulin sensitivity.

Baseline adiponectin did not, however, correlate significantly with the level of insulin sensitivity 2 years later, the investigators report. Race and total fat were, however, inversely related to future insulin sensitivity.

"Obesity is a serious risk for chronic metabolic disease among children and adolescents," Dr. Gower concluded. "This risk is greater among African Americans than Caucasians; therefore, particular attention should be paid to limiting obesity among African Americans."
Diabetes 2005;54:2772-2778.


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