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ADA: Hepatitis B Vaccine Shows Some Benefits in Preventing Diabetes

 

Study subjects who had the hepatitis B vaccination had an 81% reduction in diabetes risk….

Researchers used data on participants in the NHANES study that lasted from 2005-2010 including adult subjects (≥18 y/o) with both fasting plasma glucose and hepatitis B status. Regression analysis was used to calculate the odds ratio (OR) with 95% confidence intervals. It included adjustments of potential covariates like age, gender, BMI, race/ethnic group, smoking and alcohol use, education, and physical activity.

The study included 7,142 subjects without a history of diabetes. In the 1,412 subjects vaccinated with hepatitis B, diabetes was seen in 16 subjects (1.13%) with hepatitis B vaccination and 325 subjects (5.67%) without vaccination. The OR for diabetes was 0.19 (95%CI: 0.11-0.32). After adjustment for all covariates, the OR for diabetes was 0.48 (95%CI: 0.28-0.82).

The study shows the subjects with hepatitis B vaccination have an 81% reduction in diabetes risk though most of the subjects were younger females with lower BMIs and fasting plasma glucose.

Practice Pearls:
  • This is the first report that Hepatitis B vaccination could reduce risk of diabetes in multiple ethnic groups.
  • There is more than 50% reduction in developing diabetes for those with Hepatitis B vaccination in the study.
  • Further study is needed to examine the impact of hepatitis B vaccinations in preventing diabetes.
Presented at the American Diabetes Association 2014 Scientific Sessions; June 14, 2014