A New Diabetes Drug Class

Jun 16, 2020

Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Jacob Roberts, PharmD Candidate 2021 of University of Colorado Denver Skaggs School of Pharmacy and Pharmaceutical Sciences

Imeglimin, a new, first-in-class blood-glucose-lowering agent, proves to be safe and efficient as monotherapy and adjunctive therapy to lower A1C in patients with type 2 diabetes.

A systematic review and meta-analysis published in the British Journal of Diabetes presented promising data for Imeglimin, a medication to treat diabetes using a novel mechanism of action. This drug is currently in phase 3 trials of human studies and is likely to continue in the approval process based on currently available data.

Imeglimin is a new medication in a class of glucose-lowering agents called "glimins." Studies in animal models show that its likely mechanism of action is "via a mitochondrial mechanism to increase glucose uptake by skeletal muscle, decrease hepatic glucose output, and increase glucose-dependent insulin secretion." It may also protect endothelial cells from damage caused by glucotoxicity and have beneficial cardiovascular effects....

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