Tuesday , July 26 2016

From the Editor

July, 2016

  • 26 July

    July 26, 2016


    There are various hormones, neurotransmitters, nucleotides, and fatty acids in the pancreas that affect insulin production and secretion. Sorting all these factors out, and how we might possibly affect glucose control by mimicking  some of these compounds, has opened up new avenues of treatment. GLP-1 agonists are just one example. This week in our ...

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July, 2016

Test Your Knowledge

Question 843

In the fasting state, hyperglycemia is directly related to:


Answer: 1.: Increased hepatic glucose production

Educational Critique: Hyperglycemia is caused by a number of factors. Increased hepatic glucose production is the primary mechanism in the fasting state. In type 2 diabetes, while the islet ß-cells are still able to produce insulin, they are producing relatively insufficient amounts for the degree of insulin insensitivity. In the postprandial state, insufficient suppression of hepatic glucose production as well as decreased insulin stimulated glucose uptake at the target tissues (primarily skeletal muscle) lead to increased plasma glucose. In type 2 diabetes, pancreatic a-cell functionality also changes to a hypersecretory state of glucagon release, leading to further hepatic glucose production. Adipocyte lipolysis generates free fatty acids, which contribute to gluconeogenesis.  care.diabetesjournals.org/content/35/6/1364


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July, 2016