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From the Editor

February, 2017

  • 25 February

    Feb. 25, 2017


    Most of you know that I love to cycle, and getting in as many miles as possible is always something I am looking for. Although I consider 60 miles to be a long ride, some of my riding buddies believe that is a drop in the bucket. On Friday morning, ...

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February, 2017

Test Your Knowledge

Question 874

Which one of the following categories of glucose-lowering drugs improves insulin resistance as its primary mechanism of action?


Answer: B. Thiazolidinediones (e.g. pioglitazone)   (TZD's)

Explanation: Biguanides and thiazolidinediones are the two classes of hypoglycemia drugs that improve insulin resistance as their primary mechanism of action. Thiazolidinediones are thought to act on adipose tissue, muscle, and the liver to reduce glucose production and increase glucose use. They may also preserve pancreatic beta-cell function, thereby improving blood glucose levels. Thiazolidinediones are generally combined with other drugs, for example, metformin, in patients who do not respond to monotherapy. However, they are rather costly and should not be prescribed to patients with a history of heart failure or low bone density.


Nathan DM, et al. Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;32:193-203.


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