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Daily Archives: Dec 18, 2018

Dec. 18, 2018

Many years ago when I first got into diabetes care there was constant pushback on the idea of a pharmacist managing diabetes patients. The idea that a pharmacist could actually do pump trainings was unheard of. I thought we Pharmacists would be a natural choice because of our drug knowledge, …

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Talk About Leftovers!

As we know, the holidays are very tough for many of our patients who have diabetes and/or obesity. They may have made some changes -- big changes -- in their eating habits, only to get in trouble over the long holiday season, then have a very difficult time getting back on track. The long holiday season can be a disaster to their health. I have found that for most, having leftovers at home wreaks havoc.

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #156: Monogenic Disorders of the Beta Cell Part 6

Renal cysts and diabetes (RCAD) syndrome: HNF1B-MODY
Molecular genetics of RCAD
HNF1B is a transcription factor with a role in regulating gene expression in a number of tissues. HNF1B forms homo and heterodimers with HNF1A, is present in similar tissues although at different levels, and binds to the same DNA consensus sequence. Despite these similarities HNF1B mutations cause diabetes by a different mechanism and have a distinct phenotype. There is autosomal dominant inheritance, although up to 50% of cases arise from de novo mutations or deletions.

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