Daily Archives: Sep 4, 2018

Sept. 4, 2018

A couple of weeks ago, I received an email from NSI, the National Stem Cell Institute, that contained their latest newsletter. This one focused on using adipose tissue-derived stem cells to repair meniscus tears. This caught my eye because three of my fellow cyclists had avoided surgery by having this procedure …

Read More »

Timing Matters, But Patient Reasons May Be a Factor

This is about one patient but the situation is not unusual for many patients who have type 2 diabetes and take insulin. Woman, 67 years of age, type 2 diabetes, taking Tresiba 15u every day at 11am and Victoza every morning upon arising, about 8am. She wears a CGM. Glucose levels were in target range for some time. Family reported patient was having some subtle cognitive changes. We did send her for neurologic evaluation.

Read More »

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #141: The Genetics of Type 2 Diabetes Part 3

Identification of T2DM affecting genetic variants: The methods used to map disease-causing variation have evolved rapidly in the last decades thanks to technical advances in genotyping methods. Originally, disease-causing loci were identified primarily by linkage analysis, utilizing the long stretches of linkage in affected families. By genotyping 400–500 genetic markers, disease loci can be mapped on a genome-wide level without any prior hypothesis about which genes are involved. Finding that affected family members share a certain marker that is identical by descent (i.e., identical because it was inherited from the same parent) more often than expected by chance is evidence that a disease-causing variant is in linkage with that marker. This strategy has been very successful in mapping genetic diseases like MODY that have a strong penetrance and a known mode of inheritance.

Read More »