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Daily Archives: May 16, 2017




May 16, 2017

Last week our good friend from Diabetes Investor, David Kliff, provided us with his view on the future of insulin pumps, and all the companies that were trying to enter the market with their own pump. He seems to feel that in the long run the best product to use …

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #75: Regulation of Glucose Metabolism in Liver Part 11 of 11

Pyruvate dehydrogenase and lipogenesis: The generation of pyruvate via glycolysis and L-PK brings the chapter full circle. Tracer experiments in humans estimate PDH flux to be very small in the postabsorptive liver. However, in the fed state activation of hepatic lipogenesis requires activation of PDH flux to generate acetyl-CoA from carbohydrate. PDH consists of three subunits (E1 – E3) that catalyze the sequential decarboxylation, acetyl-CoA formation and reduction of NAD+ to NADH, respectively.

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