Tuesday , January 24 2017
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Yearly Archives: 2017




Jan. 24, 2017

dave

Many times, we become frustrated with our patients because they just don’t take diabetes seriously. One of the ways that we see this is the lack of refill persistence and medication adherence among these patients. Even with medications that you only have to take once per week, there is a ...

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Teach Not to Hate Insulin

Nurse caring about elder man

Man, 63 years of age, type 2 diabetes, obesity, hypertension and hyperlipidemia, referred to me, a CDE, to start him on and teach him how to use insulin. He has had diabetes education in the past, tried lower carb eating and physical activity, but glucose levels still elevated. He told me he felt like a failure. He said he learned he was insulin resistant, made too much insulin, which was causing his co-morbidities. He was very resistant to start insulin, especially since he thought insulin was the cause of his problem.

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #59: Mechanisms of insulin signal transduction Part 3 of 8

DeFronzoCover

Insulin receptor substrate molecules -- receptor substrate/docking protein: Following insulin binding and receptor autophosphorylation, the next committed step in signal transduction is tyrosine phosphorylation of intracellular proteins. To accomplish this, autophosphorylation of the beta subunit mediates noncovalent but stable interactions between the receptor and intracellular substrate proteins, and this positions these molecules for tyrosine phosphorylation by the activated insulin receptor kinase.

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Jan. 21, 2017

dave

It seems that we are finally acknowledging that preventing diabetes is an idea that may be worthwhile. This week, we have a feature about how to predict which children will develop diabetes in their lifetime. This gives us an earlier place to start treating prediabetes. We also can start testing ...

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