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Monthly Archives: July 2016

July 12, 2016

Pyruvate cycling pathway is a term I have not heard in many years. When I was in pharmacy school, I remember our Medicinal Chemistry professor posting a slide on the overhead, and telling us if we learned this by the end of the semester we would pass the class. Although …

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #32: Beta-Cell biology of insulin secretion Part 2 of 5

Metabolism-secretion coupling, triggering pathway: Glucose metabolism increases the cytosolic ATP concentration in pancreatic beta cells, this rise in ATP causing closure of the KATP channels and depolarization of the beta-cell membrane. Thus, KATP channels couple the cell’s metabolic state to electrical activity. The beta-cell KATP channel is composed of two subunits: Kir6.2 as a pore-forming subunit and the sulfonylurea receptor SUR1 as a regulatory subunit. Activity of the KATP channel is critical for GIIS. Membrane depolarization opens VDCCs, which allows Ca2+ influx into β cells, the resultant rise in intracellular Ca2+ triggering exocytosis of insulin granules. Thus, KATP channels and VDCCs are major ion channels required for metabolism-secretion coupling in insulin release.

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July 9, 2016

Sixteen years ago when Steve and I started this newsletter, we were sending it out to 30 pharmacists we knew. As more and more of you started subscribing and sharing our site and newsletter with others, I would sometimes sit at my desk in awe of what we had accomplished …

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Bariatric Surgery Recommendations

Are you changing your criteria for recommending metabolic surgery to your patients based on the new guidelines issued by International Diabetes Federation Taskforce on Epidemiology and Prevention of Diabetes (see article 1)?

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