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Monthly Archives: October 2014




FDA Approves Xigduo XR, a New Dapagliflozin-Metformin Combination

The once-daily oral tablet is the first in the U.S. to combine the SGLT-2 inhibitor dapagliflozin with the biguanide extended-release (XR) metformin hydrochloride.. The US Food and Drug Administration (FDA) has approved a once-daily combination of dapagliflozin and metformin hydrochloride extended-release (Xigduo XR, AstraZeneca) for the treatment of adults with …

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DPP-4 Inhibitors in Combination with Insulin Therapy for Type 2 Diabetes Patients

The addition of a DPP-4 inhibitor decreased HbA1C while not requiring an increase in insulin, and subjects remained weight neutral without experiencing an increase in hypoglycemic events… Currently approved dipeptidyl peptidase-4 (DPP-4) inhibitors include alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin. DPP-4 inhibitors work by enhancing glucose dependent insulin secretion and …

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Metformin Is Best Initial Oral Drug for Lowering Glucose Levels in Diabetes Patients

Metformin, sulfonylureas, thiazolidinedione, and DPP-4 inhibitors were compared to evaluate the effects on the time to subsequent treatment… There are many classes of oral drugs used for diabetes therapy, but there is a lack of evidence as to which drug is best for use as initial therapy. Most patients diagnosed …

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Sugar Not Addictive But Eating It Can Be

European scientists studying addiction have found that there is almost no evidence showing humans can be addicted to specific macronutrients such as sugar. Instead, the researchers suggest that obesity prevention strategies should focus on an "eating addiction," rather than specific foods. Neuroscience & Biobehavioral Reviews DOI: 10.1016/j.neubiorev.2014.08.01

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Resistance Exercise Helps to Avoid Falls

Patients with diabetic peripheral neuropathy were slower and clumsier than their healthier counterparts when going up and down stairs due in part to weak muscles, poor coordination and sensory damage, according to a study. However, researchers said resistance training may help patients build up strength and reduce the risk of …

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